Practical High-Throughput Experimentation for Chemists
نویسنده
چکیده
Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified.
منابع مشابه
PowerMV: A Software Environment for Molecular Viewing, Descriptor Generation, Data Analysis and Hit Evaluation
Ideally, a team of biologists, medicinal chemists and information specialists will evaluate the hits from high throughput screening. In practice, it often falls to nonmedicinal chemists to make the initial evaluation of HTS hits. Chemical genetics and high content screening both rely on screening in cells or animals where the biological target may not be known. There is a need to place active c...
متن کاملTracking chemical kinetics in high-throughput systems.
Combinatorial chemistry and high-throughput experimentation (HTE) have revolutionized the pharmaceutical industry-but can chemists truly repeat this success in the fields of catalysis and materials science? We propose to bridge the traditional "discovery" and "optimization" stages in HTE by enabling parallel kinetic analysis of an array of chemical reactions. We present here the theoretical bas...
متن کاملMiniaturized Reactor Concepts and Advanced Analytics for Primary Screening in High-Throughput Experimentation
The development of novel and better catalysts for chemical processes is mainly an empirical process utilizing existing technical expertise and experience. The aim of reducing time and costs has proved a powerful incentive for the development of high-throughput technologies for applications in heterogeneous and homogeneous catalysis. Obviously, there are strong analogies between the development ...
متن کاملNootropic Medicinal Plants; Evaluating Potent Formulation By Novelestic High throughput Pharmacological Screening (HTPS) Method
The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...
متن کاملVisualization of chemical space for medicinal chemists
One of the most common tasks that cheminformatics experts in pharmaceutical industry are facing practically daily is analysis and visualization of large collections of molecules. Typical areas, where this is needed are analysis and enhancement of company compound archive, analysis of high-throughput screening data, design of combinatorial libraries, chemogenomics analyses and many others. But a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017